PE-22-28 10mg

PE‑22‑28 is a synthetic, seven–amino‑acid peptide (sequence GVSWGLR), designed as a shortened analog of spadin and a potent antagonist of the TREK‑1 two‑pore potassium channel (IC₅₀ ≈ 0.12 nM) By blocking TREK‑1—expressed in brain regions tied to mood, learning, and memory—it produces rapid antidepressant effects, inducing hippocampal neurogenesis and synaptogenesis in just a few days. Animal studies indicate it alleviates depressive-like behavior in ~4 days, boosts markers like BDNF and CREB, and improves cognitive function with minimal side effects.  It also shows promise in stroke recovery and may support neuroprotection and muscle contractility via TREK‑1 modulation. In sum, PE‑22‑28 represents a fast-acting, nootropic and neuroregenerative spadin analog under active preclinical research.